团队名称:纳米生物材料与再生医学研究中心(Research Center for Nano-biomaterials & Regenerative Medicine)
团队目标与定位:
立足纳米生物材料与再生医学的国际前沿和发展方向,围绕国民健康和社会经济发展的重大需求,以组织再生和功能重建的生物材料及医用植入体的应用基础及工程化研究为总体研究目标,重点发展用于再生器官的生物材料及其相关的关键科学问题,突破生物材料产业化过程中的工程技术瓶颈、推动科研成果产业化、探索新形势下生物材料学学科建设和人才培养的模式,是一支集培养人才、发展学术、服务社会三大功能于一身的生物材料科研团队。
研究方向:
1. 生物材料
2. 组织工程
3. 3D生物打印与器官芯片
4. 药物缓释载体及靶向治疗
团队成员:黄棣,魏延,连小洁,胡银春,赵丽琴,等等
团队介绍:
本团队以纳米生物材料与再生医学研究中心、生物医学工程实验中心为平台,依托材料强度与结构冲击山西省重点实验室,以临床需求为导向,开展纳米生物材料制备及评价研究,并与国内外多家科研单位开展合作。
团队现有固定成员12人,教授1人,副教授5人,讲师6人,均具博士学位,平均年龄36岁,8人具有海外学习经历。承担国家自然科学基金8项,省部级、企业委托项目20余项。其中山西省三晋英才4人,发表论文200余篇。
代表性科研项目及成果介绍:
1. 国家自然科学基金,22307092,仿生纳米酶构筑的BACE1靶向调控平台用于阿尔茨海默症的多级协同治疗,2024/01-2026/12,30万元。
2. 国家自然科学基金,12272253,应力刺激下成骨细胞介导类骨磷灰石形成机理研究,2023/01-2026/12,56万元。
3. 国家自然科学基金,12202302,力学刺激下基于胶原的软骨植入物降解与软骨再生机制研究,2023/01-2025/12,30万元。
4. 国家自然科学基金,12002231,PD-L1蛋白的唾液酸修饰在肝癌干细胞自我更新及免疫逃逸中的作用及分子机制,2022/01-2024/12,30万元。
5. 国家自然科学基金,12002231,主动脉管壁板层结构响应局部载荷的生物力学机制研究,2021/01-2023/12,24万元。
6. 国家自然科学基金,11902214,力学刺激下HA/PU复合组织工程骨的构建及其生物学响应机制研究,2020/01-2022/12,27万元。
7. 国家自然科学基金,11802197,基于水凝胶多级结构仿生设计关节软骨替代材料及其粘弹性力学行为研究,2019/01-2021/12,28万元。
8. 国家自然科学基金,11502158,力-化学协同作用纳米磷灰石取向生长研究,2016/01-2018/12,25万元。
9. 国家自然科学基金,51502192,微纳米矿化丝素/硫酸钙双缓释系统的构建及其促进感染性骨缺损修复的机理研究,2015/01-2018/12,24万元。
10. 国家自然科学基金,51503140,卵巢癌细胞表面纳米粒子壳化的靶向缓释系统构建及纳米壳化抗癌效能评价,2015/01-2018/12,20万元。
代表性论文和专著
1. Chapters: Cui Wenguo, Zhao Xin, Theranostic bionanomaterials. Cao Xia, Huang Di, Zhang Yu Shrike, Bionanomaterials as imaging contrast agents, 2019, 401-416. ISBN: 978-0-12-815341-3.
2. Xu Huilun, Liu Zhengjiang, Wei Yan, Hu Yinchun, Zhao Liqin, Wang Longfei, Liang Ziwei, Lian Xiaojie, Chen Weiyi, Wang Jiucun, Yu Zhaoyan, Ma Xudong, Huang Di, Complexation-induced resolution enhancement pleiotropic small diameter vascular constructs with superior antibacterial and angiogenesis properties, Advanced Healthcare Materials, 2023, 2301809.
3. Cao Yu, Wang Longfei, Zhang Xiumei, Lu Yi, Wei Yan, Liang Ziwei, Hu Yinchun, Huang Di, Double-crosslinked PNIPAM-based hydrogel dressings with adjustable adhesion and contractility, Regenerative Biomaterials, 2023, rbad081.
4. Xu Huilun, Liu Kejun, Su Yimeng, Liu Zhengjiang, Wei Yan, Hu Yinchun, Zhao Liqin, Chen Lingfeng, Liao Xiaojie, Huang Di, Rapid formation of ultrahigh strength vascular graft: Prolonging clotting time micro-dimension hollow vessels with interpenetrating polymer networks, Composites Part B Engineering, 2023, 250, 110456.
5. Su Yimeng, Zhang Xiumei, Wei Yan, Gu Yu, Xu Huilun, Liao Ziming, Du Jingjing, Hu Yinchun, Lian Xiaojie, Chen Weiyi, Deng Yi, Huang Di, Nanocatalytic hydrogel with rapid photodisinfection and robust adhesion for fortified cutaneous regeneration, ACS Applied Materials & Interfaces, 2023, 15(5), 6354-6370.
6. Niu Xiaolian, Xu Zhiwei, Di Mingzhao, Huang Di, Li Xiaoming, Bioreactor strategies for tissue-engineered osteochondral constructs: Advantages, present situations and future trends, Composites Part B Engineering, 2023, 259, 110736.
7. Liao Ziming, Zhang Luyao, Lan Weiwei, Du Jingjing, Hu Yinchun, Wei Yan, Hang Ruiqiang, Chen Weiyi, Huang Di, In situ titanium phosphate formation on titanium implant as an ultrahigh linking with nano-hydroxyapatite coating for rapid osseointegration, Biomaterials Science, 2023, 11, 2230-2242.
8. Xu Haofeng, Xu Hao, Ma Shilong, Wei Yan, He Xuhong, Guo Chaiqiong, Wang Yuhui, Liang Ziwei, Hu Yinchun, Zhao Liqin, Lian Xiaojie, Huang Di, Biofunctional electrospun poly(L-lactic acid) membranes incorporating black phosphorus nanosheets and nano-zinc oxide for enhanced biocompatibility and antibacterial properties in catheter materials, Journal of the Mechanical Behavior of Biomedical Materials, 2023, 142, 105884.
9. Liang Ziwei, Wang Yuhui, Wang Jiapu, Xu Tao, Ma Shilong, Liu Qi, Zhao Liqin, Wei Yan, Lian Xiaojie, Huang Di, Multifunctional Fe3O4-PEI@HA nanoparticles in the ferroptosis treatment of hepatocellular carcinoma through modulating reactive oxygen species, Colloids and Surfaces B: Biointerfaces, 2023, 227, 113358.
10. Ma Shilong, Wei Yan, Sun Ruize, Xu Haofeng, Liu Xuanyu, Wang Yuhui, Liang Ziwei, Hu Yinchun, Lian Xiaojie, Ma Xiaolu, Huang Di, Calcium phosphate bone cements incorporated with black phosphorus nanosheets enhanced osteogenesis, ACS Biomaterials Science & Engineering, 2023, 9(1), 292-302.
11. Wang Yuhui, Ma Shilong, Liu Xuanyu, Wei Yan, Xu Haofeng, Liang Ziwei, Hu Yinchun, Lian Xiaojie, Huang Di, Hyaluronic acid mediated Fe3O4 nanocubes reversing the EMT through targeted cancer stem cell, Colloids and Surfaces B Biointerfaces, 2023, 222, 113071.
12. Zhang Xiumei, Liu Kejun, Qin Miao, Lan Weiwei, Wang Longfei, Liang Ziwei, Li Xiaochun, Wei Yan, Hu Yinchun, Zhao Liqin, Lian Xiaojie, Huang Di, Abundant tannic acid modified gelatin/sodium alginate biocomposite hydrogels with high toughness, antifreezing, antioxidant and antibacterial properties, Carbohydrate Polymers, 2023, 309, 120702.
13. Xu Mengjie, Liu Tingting, Qin Miao, Cheng Yizhu, Weiwei Lan, Niu Xiaolian, Wei Yan, Hu Yinchun, Lian Xiaojie, Zhao Liqin, Chen Song, Chen Weiyi, Huang Di, Bone-like hydroxyapatite anchored on alginate microspheres for bone regeneration, Carbohydrate Polymers, 2022, 287, 119330.
14. Ting Zhang, Hao Xu, Yonggang Zhang, Siruo Zhang, Xia Yang, Yan Wei, Di Huang, Xiaojie Lian. Fabrication and characterization of double-layer asymmetric dressing through electrostatic spinning and 3D printing for skin wound repair, Materials & Design, 2022, 218: 110711.
15. Huang Di, Liu Tingting, Liao Junlong, Maharjan Sushila, Xie Xin, Pérez Montserrat, Anaya Ingrid, Wang Shiwei, Alan Tirado Mayer, Kang Zhixin, Kong Weijia, Mainardi Valerio Luca, Garciamendez Carlos Ezio, Garcia German, Morreti Matteo, Zhang Weijia, Gu Zhongze, Ghaemmaghami Amir M, Zhang Yu Shrike, Reversed-engineered human alveolar lung-on-a-chip model, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118, 19, e2016146118.
16. Xu Mengjie, Qin Miao, Cheng Yizhu, Niu Xiaolian, Kong Jinlong, Zhang Xiumei, Huang Di, Wang Huanan, Alginate Microgels as delivery vehicles for cell-based therapies in tissue engineering and regenerative medicine, Carbohydrate Polymers, 2021, 266, 118128.
17. Zhao Ya, Bai Long, Sun Yonghua, Yao Xiaohong, Huang Xiaobo, Hang Ruiqiang, Huang Di, Low-temperature alkali corrosion induced growth of nanosheet layers on NiTi alloy and their corrosion behavior and biological responses, Corrosion Science, 2021, 190, 109654.
18. Lan Weiwei, Xu Mengjie, Qin Miao, Cheng Yizhu, Zhao Ya, Huang Di, Wei Xiaochun, Guo Yongchang, Chen Weiyi, Physicochemical properties and biocompatibility of the bi-layer polyvinyl alcohol-based hydrogel for osteochondral tissue engineering, Materials & Design, 2021, 204, 109652.
19. Niu Xiaolian, Wang Longfei, Xu Mengjie, Qin Miao, Zhao Liqin, Wei Yan, Hu Yinchun, Lian Xiaojie, Liang Ziwei, Chen Song, Chen Weiyi, Huang Di, Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration, Carbohydrate Polymers, 2021, 260, 117769.
20. Zhao Ya, Sun Yonghua, Lan Weiwei, Wang Zhong, Zhang Yi, Huang Di, Yao Xiaohong, Hang Ruiqiang, Self-assembled nanosheets on NiTi alloy facilitate endothelial cell function and manipulate macrophage immune response, Journal of Materials Science & Technology, 2021, 78, 110-120.
21. Zhang Xiumei, Miao Fenyan, Niu Lulu, Wei Yan, Hu Yinchun, Lian Xiaojie, Zhao Liqin, Chen Weiyi, Huang Di, Berberine carried gelatin/sodium alginate hydrogels with antibacterial and EDTA-induced detachment performances, International Journal of Biological Macromolecules, 2021, 181, 1039-1046.
22. Huang Di, Lin Qiaoxia, Zhou Yujie, Li Jingxuan, Wei Yan, Hu Yinchun, Lian Xiaojie, Chen Song, Chen Weiyi, Ag Nanoparticles Incorporated Tannic Acid/Nanoapatite Composite Coating on Ti Implant Surfaces for Enhancement of Antibacterial and Antioxidant Properties, Surface & Coatings Technology, 2020, 399, 126169.
23. Chen Song, Shen Lulu, Huang Di, Du Juan, Fan Xiaoyu, Wei Aili, Jia Lan, Chen Weiyi, Facile synthesis, microstructure, formation mechanism, in vitro biocompatibility, and drug delivery property of novel dendritic TiO2 nanofibers with ultrahigh surface area, Materials Science & Engineering C, 2020, 115, 111100.
24. Lu Zhenxiao, Zhai Yanjun, Wang Nana, Zhang Yaohui, Xue Pan, Guo Meiqing, Tang Bin, Huang Di, Wang Wenxian, Bai Zhongchao, Dou Shixue, FeS2 nanoparticles embedded in N/S co-doped porous carbon fibers as anode for sodium-ion batteries, Chemical Engineering Journal, 2020, 380: 122455.
25. Weng Zeming, Bai Long, Liu Yanlian, Sun Yonghua, Zhang Xiangyu, Huang Xiaobo, Huang Di, Yao Xiaohong, Hang Ruiqiang, Ostogenic activity, antibacterial ability and Ni release of Mg-incorporated Ni-Ti-O nanopore coatings on NiTi alloy, Applied Surface Science, 2019, 486: 441-451.
26. Zhan Yan, Ting Geng, Liu Yingliang, Hu Chaofan, Zhang Xuejie, Lei Bingfu, Zhuang Jianle, Wu Xu, Huang Di, Xiao Guanjun, Zou Bo, Near-ultraviolet to near-infrared fluorescent nitrogen doped carbon dots with two-photon and piezochromic luminescence, ACS Applied Materials Interfaces, 2018, 10 (33), 27920-27927.
27. Lin Qiaoxia, Huang Di, Du Jingjing, Wei Yan, Hu Yinchun, Lian Xiaojie, Xie Xin, Chen Weiyi, Zhang Yu Shrike, Nano-hydroxyapatite crystals formation based on calcified TiO2 nanotube arrays, Applied Surface Science, 2019, 478: 237-246.
28. Bai Long, Du Zhibin, Du Jingjing, Yao Wei, Zhang Jiaming, Weng Zeming, Liu Si, Zhao Ya, Liu Yanlian, Zhang Xiangyu, Huang Xiaobo, Hang Ruiqiang, Huang Di, Tang Bin, Xiao Yin, A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration, Biomaterials, 2018, 162: 154-169.
29. Hu Yinchun, Zhang Xuerong, Qiu Maibo, Wei Yan, Zhou Qiong, Huang Di, From coffee ring to spherulites ring of poly(ethylene oxide) film from drying droplet, Applied Surface Science, 2018, 434: 626-632.
30. Bai Long, Liu Yanlian, Du Zhibin, Weng Zhiming, Yao Wei, Zhang Xiangyu, Huang Xiaobo, Yao Xiaohong, Ross Crawford, Hang Ruiqiang, Huang Di, Tang Bin, Xiao Yin, Differential effect of hydroxyapatite nano-particle vs nano-rod decorated titanium micro-surface on osteointegration, Acta Biomaterialia, 2018, 76, 344-358.
学术交流与科研活动:
1. 2023第二届团泊湖中医药现代化论坛并做邀请报告(邀请报告),2023.6.1-2.
2. 2023中国生物医学工程大会暨创新医疗峰会(邀请报告),2023.5.19-21.
3. 2023第一届生物材料与医疗器械赣江学术论坛(邀请报告),2023.4.7-9
4. 2021-2022中国生物医学工程大会暨创新医疗峰会(邀请报告),2022.4.21-23.
5. 2022全国生物医用复合材料学术年会(邀请报告),2022.10.12-13.
6. 2021中国生物材料大会(邀请报告),上海,2021.10.11-14.
7. 2021全国生物力学大会,贵阳,2021.10.05-09
8. 2021全国高聚物分子与结构表征学术研讨会,贵阳, 2021.5.21-23
9. 2020全国生物力学优秀青年学者学术会议(邀请报告),杭州, 2020.11.20-22.
10. 2019中国生物医学工程大会暨创新医疗峰会(邀请报告),济南, 2019.11.14-16.
11. 2019年中国生物材料大会暨国际先进生物材料大会,大连, 2019.8.22-25.
12. 第七届中美生物医学工程暨海内外生物力学学术研讨会,重庆, 2019.7.20-24.
13. 第十三届上海国际骨科前沿技术与临床转化学术会议(邀请报告),上海, 2019.5.3-5.
14. 2019生物力学在临床及康复领域应用国际学术研讨会,北京, 2019.8.11-12.
15. 5th Symposium on innovative Polymers for Controlled Delivery, Suzhou, China, 2018.9.14-2018.9.17.
16. 第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议,中国,西安, 2018.8.17-21. 优秀学术报告奖(胡银春、林巧霞).
17. 中国生物材料大会,中国,南昌, 2017.10.27-29, 2017第三届届全国生物力学青年学者学术研讨会,重庆,2018.05.
18. 第十六届全国青年材料科学技术研讨会,中国,天津, 2017.10.13-15.
19. 2017年中国生物医学工程大会,中国,北京,2017.4.20-22.
20. 第八届全国组织工程与再生医学大会暨第六届全国骨科修复、重建、再生与康复学术研讨会,中国,重庆, 2017. 6.3-5.
21. 第6届中美生物医学工程暨海内外生物力学学术研讨会,中国,上海2016.8.5-8.
22. 第十一届全国生物力学学术会议暨第十三届全国生物流变学学术会议,中国,太原,2015.10.10-14.
23. 中国生物材料大会暨中美生物材料学会第三次专题论坛,中国,海口, 2015.11.19-22.
在读博士和研究生数量:
在读博士生4人,在读硕士研究生50余名。
所获荣誉:
1. 2023第八届全国大学生生命科学竞赛(科学探究类)全国一等奖(指导老师:梁紫微)。
2. 2022山西省优秀硕士学位论文(张秀梅)
3. 2022研究生国家奖学金(徐慧伦)
4. 2022第七届全国大学生生命科学竞赛(科学探究类)全国二等奖(指导老师:梁紫微)。
5. 2021研究生国家奖学金(张秀梅、丁慧秀)
6. 2021山西省研究生教育创新项目(张秀梅、丁慧秀)
7. 2021第六届全国生物医学工程创新设计竞赛二等奖(指导老师:胡银春)
8. 2021第六届全国生物医学工程创新设计竞赛三等奖(指导老师:黄棣)
9. 2021太原理工大学优秀硕士学位论文(牛小连)
10. 2020第六届山西省“互联网+”大学生创新创业大赛银奖(指导教师:黄棣)
11. 2020研究生国家奖学金(兰伟伟、徐梦洁、牛小连、秦苗)
12. 2020山西省研究生教育创新项目(兰伟伟、徐梦洁)
13. 2020山西省优秀硕士学位论文(林巧霞)
14. 2019中国康复辅助器具创新设计竞赛优秀奖(指导老师:黄棣)
15. 2019第五届全国生物医学工程创新设计竞赛一等奖(指导老师:胡银春)
16. 2019第五届全国生物医学工程创新设计竞赛二等奖(指导老师:黄棣)
17. 2019第五届全国生物医学工程创新设计竞赛三等奖(指导老师:赵丽琴)
18. 2019研究生国家奖学金(林巧霞、徐睿)
19. 2019太原理工大学优秀硕士学位论文(殷萌)
20. 2019太原理工大学大学生创新创业优秀项目(指导老师:赵丽琴)
21. 2018创青春全国大学生创业大赛铜奖(指导老师:连小洁)
22. 2018研究生国家奖学金(王志微、战岩)
23. 2018山西省研究生教育创新项目(殷萌)
24. 2018太原理工大学大学生创新创业优秀项目(指导老师:黄棣)
25. 2018太原理工大学优秀本科毕业论文(指导老师:黄棣)
26. 2017山西省研究生教育创新项目(刘世超)
27. 2017太原理工大学特优本科毕设论文(指导老师:黄棣,杜晶晶)
28. 2017太原理工大学大学生创新创业优秀项目(指导老师:黄棣)
重要的仪器设备及实验室:
1. 纳米生物材料制备平台:静电纺丝机(KH-1089),喷雾干燥机(BILON-6000Y),高温炉(GSL-1700X,ZY-L1400),电化学工作站,冷冻干燥机,生物打印机,激光切割机,微流控器官芯片等;
2. 纳米生物材料检测平台:场发射扫描电镜(JSM-7100F,附EDS、EBSD、离子溅射仪),X射线衍射仪(DX-2700BH,附掠入射平台),红外光谱仪(Nicolet IS10,附ATR),四探针测试仪(SB120),粘度计(NDJ-8S)等,紫外可见分光光度计(SP-754),疲劳力学试验机(Bose3200),万能力学试验机;
3. 纳米生物材料生物学评价平台:细胞实验室(Nicon TiS荧光倒置相差显微镜,Thermo Forma311细胞培养箱,Biorad iMark酶标仪,高速冷冻离心机,超净工作台,十万级洁净安全柜;超纯水系统,灭菌系统等);分子生物学实验室(PCR,电泳系统,凝胶成像系统,超声细胞粉碎仪,碎冰机等);微生物实验室(细菌培养箱、超净工作台、生物显微镜、恒温摇床等);动物实验室(无影灯,锉磨机,手术器械系统,动物饲养系统等)。