Education
2009-2012 |
East China University of Science and Technology, China |
Biochemical engineering |
Ph.D. |
2003-2006 |
ShanXi University , China |
Microbiology |
Master |
1999-2003 |
Southwest Forestry University , China |
Biotechnology |
Bachelor |
Professional Experience
2014-now |
|
Taiyuan University of Technology, China |
2012-2014 |
|
National University of Singapore |
2010-2012 |
|
HuaBao Food Flavor and Fragrance (ShangHai) Co., Ltd |
Research interests
- Biocatalysis and Biotransformation
- Biodegradation
Recent work related to some topics in Biocatalysis and Biotransformation, mainly focused on the preparation of high value-added chiral chemicals by cascade biocatalysis, such as cascade biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure β-amino alcohols. Cascade biocatalysis for asymmetric Markovnikov hydroamination of alkenes to chiral amines. Interests are also including the genome mining of interest and important industry enzymes for chiral drug intermediate synthesis.
Publications
> 26 articles and 4 patents
H index : X
Selected publications
1. Jian-Dong Zhang*, Ya-Wen Chang, Rui Dong, Xiao-Xiao Yang, Li-Li Gao, Jing Li, ShuangPing Huang, Xing-Mei Guo, Chao-Feng Zhang and Hong-Hong Chang. Enantioselective cascade biocatalysis for deracemization of racemic β-amino alcohols to enantiopure (S)-β-amino alcohols employing cyclohexylamine oxidase and ω-transaminase. ChemBioChem 10.1002/cbic.202000491.
2. Jian-Dong Zhang, * Jian-Wei Zhao, Li-Li Gao, Jing Zhao, Hong-Hong Chang, Wen-Long Wei. One-pot three‐step consecutive transformation of L-α-amino acids to (R)- and (S)-vicinal 1,2-diols via combined chemical and biocatalytic process. ChemCatChem, 2019, 11: 5032-5037
3. Jian-Dong Zhang*, Xiao-Xiao Yang, Qiao Jia, Jian-Wei Zhao, Li-Li Gao, When-Chao Gao, Hong-Hong Chang, Wen-Long Wei and Jian-He Xu , Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system. Catal. Sci. Technol., 2019, 9, 70-74.
4. Zhi-Mei Cui, Jian-Dong Zhang*, Xiao-Jun Fan, Gao-Wei Zheng Hong-Hong Chang*, Wen-Long Wei. Highly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-phenyl-1, 2-ethanediol by two substrate tolerance carbonyl reductases with cofactor regeneration. Journal of Biotechnology. 2017, 243: 1–9.
5. Jian-Dong Zhang*, Hua-Lei Wu, Tong Meng, Chao-Feng Zhang, Xiao-Jun Fan, Hong-Hong Chang, Wen-Long Wei. A high-throughput microtiter plate assay for the discovery of active and enantioselective amino alcohol-specific transaminases. Analytical Biochemistry. 2017, 518: 94-101.
6. Jian-Dong Zhang, Shuke Wu, Jinchuan Wu, Zhi Li. Enantioselective Cascade Biocatalysis via Epoxide Hydrolysis and Alcohol Oxidation: One-Pot Synthesis of (R)-α-Hydroxy Ketones from Meso- or Racemic Epoxides. ACS Catalysis. 2015,5:51-58.
7. Jian-Dong Zhang, Tingting Xu, Zhi Li. Enantioselective Biooxidation of Racemic Trans-Cyclic Vicinal Diols: One-pot Synthesis of Both Enantiopure (S, S)-Cyclic Vicinal Diols and (R)-α-Hydroxy Ketones. Adv. Synth. Catal. 2013. 16: 3147-3153.
CONFERENCES
05/2013 The 5th Annual General Meeting of the Singapore catalysis society (SCS), Singapore. (Poster)
05/2012 Bioenergy Society of Singapore (BESS) workshop on Bioresources to Fuels and Chemicals 2012, Singapore.
10/2009 The 5th Sino-US Conference of Chemical Engineering, 2009, Beijing, China. (Poster)
08//2009 The 4th International Symposium on Bioprocess and Biosystems Engineering (ISBBE 2009), Shanghai, China. (Poster)
HONORS & AWARDS
2018 Shanxi Province “Sanjin talents” support plan.
2018 The title of outstanding communist party member of College of Biomedical Engineering, TYUT.
2018 The outstanding scientific and technical worker of College of Biomedical Engineering, TYUT.
2020-now Young editorial board member of Bioresources and Bioprocessing
2010-now Reviewer of manuscripts for journals including ACS Sustainable Chemistry & Engineering, Bioresource and bioprocess, Catalysis letters, Journal of biotechnology, Journal of Molecular Catalysis A-Chemical, Journal of organic chemistry, Biocatalysis and Biotransformation, Process biochemistry, etc
