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Dr. Wenchao Gao is an associate professor at Department of Biological & Pharmaceutical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P.R. China E-mail: gaowenchao@tyut.edu.cn Website: https://www.x-mol.com/groups/gaowenchao |
Education
2008-2013 |
Nankai University, China |
Organic Chemistry |
Ph.D. |
2004-2008 |
Northwest A&F University, China |
Applied Chemistry |
Bachelor |
Professional Experience
2013-now |
Accosiate Professor |
Taiyuan University of Technology, China |
2017-2018 |
Visiting Scholar |
Cardiff University, U K |
2019-now |
Post Doctoral |
East China Normal University, China |
Research interests
- Synthesis & linkage of drugs
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Recent work is focused on some topics in the design and synthesis of novel linkers in multi-target drugs (ADCs, DELs, and PROTECs), and the aim is to achieve the intelligent linkage and release of drug conjugates. Interests are also including the construction of key frameworks with biological activities, and the modification of medicinal intermediates.
Publications
> 20 articles and 5 patents
H-index 15
Selected publications
1. Steric and Stereoscopic Disulfide Construction for Cross-linkage via N-Dithiophthalimides. Wen-Chao Gao, Jun Tian, Yuzhu Shang and Xuefeng Jiang,* Chem. Sci. 2020, 11, 3903-3908.
2. N‑Alkynylthio Phthalimide: A Shelf-Stable Alkynylthio Transfer Reagent for the Synthesis of Alkynyl Thioethers. Wen-Chao Gao,* Yu-Zhu Shang, Hong-Hong Chang, Xing Li, Wen-Long Wei, Xin-Zhang Yu, and Rong Zhou,* Org. Lett. 2019, 21, 6021−6024.
3. Copper(II)-Catalyzed Four-Component Oxysulfonylation/Diazenylation: Synthesis of α-Arylhydrazo-β-keto Sulfones. Wen-Chao Gao,* Yu-Fei Cheng, Yu-Zhu Shang, Hong-Hong Chang, Xing Li, Rong Zhou,* Yan Qiao, and Wen-Long Wei, J. Org. Chem. 2018, 83, 11956-11962.
4. AlCl3-Catalyzed Intramolecular Cyclization of N-Arylpropynamides with N-Sulfanylsuccinimides: Divergent Synthesis of 3-Sulfenyl Quinolin-2-ones and Azaspiro[4,5]trienones. Wen-Chao Gao,* Tao Liu, Yu-Fei Cheng, Hong-Hong Chang, Xing Li, Rong Zhou,* Wen-Long Wei, and Yan Qiao, J. Org. Chem. 2017, 82, 13459−13467.
5. Hypoiodite-catalysed oxidative cyclisation of Michael adducts of chalcones with 1,3-dicarbonyl compounds: a facile and versatile approach to substituted furans and cyclopropanes. Wen-Chao Gao,* Fei Hu, Jun Tian, Xing Li, Wen-Long Wei, Hong-Hong Chang,* Chem. Commun. 2016, 52, 13097-13100.
Others. Such as Lectures/Conferences/Awards/Honors/Projects
